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Spinal tanycytic ependymoma in four Korean patients: case series
Jaeyon Choi, Seong Yi
Yonsei University College of Medicine, Seoul, Korea
Correspondence  Seong Yi ,Tel: 82-2-2228-2174, Fax: 82-2-393-9979 , Email: sl.sevspine@gmail.com
Received: July 17, 2018;  Accepted: August 21, 2018.  Published online: August 21, 2018.
ABSTRACT
Objective:
Tanycytic ependymoma is a rare variant of ependymoma usually arising in the intramedullary spine found usually on cervical and mid-thoracic level. Herein, we report our experience of treating rare cases of tanycytic ependymoma.
Method:
Four patients were studied by retrospective analysis. A pathologist analyzed immunohistochemical results for diagnosis, and postoperative neurologic examination and MRI were followed up.
Results:
In preoperative MRI study, the tumors were enhanced on T1-weighted imaging, which showed well-defined lesion. We thought that our patient’s tumors were schwannoma. However, spindle cell and immunohistochemical staining of the permanent section revealed strong immunoreactivity for glial fibrillary acidic protein, confirming that tumors were tanycytic ependymoma. Postoperative neurological symptoms are almost absent. The long-term clinical symptoms for tanycytic ependymomas is the same or slightly better than that for other ependymoma subtypes.
Conclusion:
Diagnosis of tanycytic ependymoma is challenging, as the morphology of the lesions resemble those found in schwannoma and astrocytomas. Differential diagnosis is extremely important for management and prognosis and differentiation of tanycytic ependymomas from astrocytomas and schwannomas, although a correct histological diagnosis may be difficult. However, immunohistochemical staining may be helpful in differential diagnosis.
Key words: astrocytoma; schwannoma; tanycytic ependymoma
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Spinal Tanycytic Ependymoma in Four Korean Patients: Case Series  2018 October;4(2)
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