Idiopathic Spinal Cord Herniation at Thoracic Spine Level: A Case Report

Article information

Nerve. 2021;7(1):24-26
Publication date (electronic) : 2021 April 30
doi : https://doi.org/10.21129/nerve.2021.7.1.24
Department of Neurosurgery, Dankook University College of Medicine, Cheonan, Republic of Korea
Corresponding author: Young Jin Kim Department of Neurosurgery, Dankook University Hospital, Dankook University College of Medicine, 201 Manghyang-ro, Dongnam-gu, Cheonan 31116, Republic of Korea Tel: +82-41-Fax: +82-41-550-7060 E-mail: spine1225@naver.com
Received 2021 March 30; Revised 2021 April 17; Accepted 2021 April 19.

Abstract

Idiopathic spinal cord herniation (ISCH) is a rare disease. It especially occurs at the thoracic level through a ventral dural defect without a definite pathophysiology. More patients have been diagnosed recently because both technical quality and accessibility to magnetic resonance image have increased. Symptoms of ISCH are related to anterior cord syndrome due to the location of cord herniation in the ventral portion. Progressive myelopathy and complete or partial Brown-Sequard syndrome are also commonly observed. Spinal cord reposition or dural defect repair are treatments of choice. We present a case of ISCH at T4-5 level of a patient whose symptom of chronic back pain turned into Brown-Sequard syndrome. It was managed with surgical treatment, spinal cord reposition, and dural defect repair with an artificial dura patch. En bloc laminoplasty was also performed to prevent deformity and CSF leakage.

INTRODUCTION

Herniation of the spinal cord specifically presents at the thoracic level through a ventral dural defect without a definite pathophysiology 1,5-7). Since its initial description by Wortzman et al. 12) in 1974, more patients have been diagnosed recently because both technical quality and accessibility to magnetic resonance imaging (MRI) have increased 3,7,11). Its clinical symptoms show progressive myelopathy including Brown-Sequard syndrome because the location of the cord herniation is at the ventral portion. About two-thirds of cases occur in female patients with an insidious symptom onset 3). Spinal cord reposition and dural defect repair with an artificial dura are the best surgical options.

We introduce a case of idiopathic spinal cord herniation (ISCH) at T4-5 level successfully managed with surgical treatment, spinal cord reposition, and dural defect repair. After reposition was done, en bloc laminoplasty at the T4-5 level was also performed to prevent cerebrospinal fluid (CSF) leakage with compression and preserve the function of muscles to reattach at the lamina, thus protecting from the outside environment after recovery from surgery.

CASE REPORT

A 42-year-old male without any underlying disease suffered from progressive motor weakness and paresthesia. The patient complained about his deteriorated symptoms for five months. These deteriorated signs were progressive paresthesia, loss of temperature, sensation for pain in his left lower extremities, and decreased motor grade on his right side. In physical examination, the patient’s motor grade was 4~4+ on both side which makes the patients hard to ambulate. Decreased right foot dorsiflexion with a grade of about 3 was also observed. Electromyography performed for intraoperative monitoring (IOM) before surgical treatment suggested a central conduction defect on both lower extremities. A cervicothoracic junction MRI revealed ISCH at the T4-5 level and CSF collection at dilatated subarachnoid space. Both MRI and computed tomography (CT)-myelography was performed after admission for evaluation (Fig. 1, 2). Under general anesthesia, neuromonitoring with motor evoked potentials (MEPs) and somatosensory evoked potentials (SEPs) was put in place and the patient was turned into a prone position. After identification of the thoracic level with a C-arm, total laminectomy was performed with a bone scalpel at T4 and T5 levels. Under the microscope, the dura was opened sagittally. After cutting ipsilateral dentate ligaments and carefully pushing spinal cord towards the contralateral side, spinal cord herniation and dural defect were visible through the microscope. Oval-shaped about 2 cm size dural defect and cord herniation without inflammation or adhesion was observed at the ventral portion of the spinal cord. The margin was soft and there was no sign of spinal cord swelling. Using a micro-dissector, a dural defect was explored and reposition of the herniated spinal cord was performed carefully. An artificial dura was overlapped intradurally to cover the dural defect (Fig. 3). Due to the size of dural defect, we decided to overlapping the defect with an artificial dura instead of a suture. After overlapping, the dura incision was closed tightly with a continuous suture. No MEP or SEP alteration was noted during the entire procedure. Preserving the muscle’s function by reattaching the muscle to the reinserted bone after surgery for protection from external injury was considered (Fig. 4).

Fig. 1.

Imaging features of idiopathic spinal cord herniation. Magnetic resonance imaging T2 sequence showed a fluid collection at the dorsal portion of the T4-5 level with a sharp angulation of the thoracic cord suggesting ventral protrusion of spinal cord.

Fig. 2.

Sagittal and axial computed tomography myelogram images demonstrating sharp angulation of the thoracic cord, cerebrospinal fluid collection, and widening of the dorsal subarachnoid space.

Fig. 3.

Intraoperative view under a microscope. Herniation of spinal cord and dural defect are also observed. Oval-shaped 2 cm size dural defect and herniation were observed and there was no sign of adhesion or inflammation and spinal cord swelling.

Fig. 4.

Simple pictures for intraoperative view while overlapping the dura. The dura was wrapped with artificial dura. After wrapping, the dura was tightly sutured with continuous suture to prevention recurrence.

Symptoms were improved after surgery. Paresthesia and motor weakness were improved and the patient was discharged 7 days after the surgery. When the patient came to the hospital after discharge, there was no neurologic deficit postoperatively. MR image at the follow-up showed no recurrence of spinal cord herniation (Fig. 5).

Fig. 5.

Simple pictures for intraoperative view while overlapping the dura. The dura was wrapped with artificial dura. After wrapping, the dura was tightly sutured with continuous suture to prevention recurrence.

DISCUSSION

Although ISCH is a rare disease, its diagnosis and treatment are important because it is one of the spinal cord lesions that could be cured with surgical repositioning and dura repair. Diagnosis is usually done with MRI. CT-myelography can also be used based on radiographic features such as ventral herniation of the spinal cord, abnormal dilatation of the subarachnoid space, and contracture or torsion the spinal cord 1).

Most clinical manifestations observed in other cases are ipsilateral hemiparesis with sensory loss and vibration, loss of pain and temperature at the contralateral side, and Brown-Sequard syndrome. Some cases of bilateral motor weakness and bowel and bladder dysfunction have been reported 1). In the present case, the patient’s initial clinical manifestation was a loss of sensory on the left side due to dysfunction of the lateral spinothalamic tract and progressive spinal cord herniation induced motor weakness of lower extremities. However, proprioception and vibration were relatively intact because the posterior portion of the cord was affected after the progression of the spinal cord herniation.

The pathophysiology of ISCH remains unclear. A few theories have been suggested. In these theories, the critical point is how dural defects are formed. A history of trauma may be the reason for ISCH. This was first reported by Tekkök 11). The author explained that a traumatic event 35 years ago might not have a large impact on the dural defect.

Repetition of minor trauma might cause ISCH 3). However, it has not been reported yet. Most cases of ISCH are related to subarachnoid cysts because abnormal dilatation of the subarachnoid space is considered to be the result of cord herniation. Erosion of the dura due to compression has been reported as a cause of ISCH 2,8). Another theory is a congenital defect of meninges. However, all cases reported in the past did not detect any spinal anomaly at other spine levels. Duplication of meninges in the inner layer at the ventral portion causing herniation and incarceration is also another theory 10), but there is no affirmation of radiological or pathophysiological evidence.

Progression of the spinal cord herniation is sustained after the cord is placed on the dural defect point and adhesion is started 4). Due to connecting of the subarachnoid and epidural space, CSF can move into the cyst by pulsation. When adhesion between the defect and cord is completed, the pulsatile CSF can push the cord out of the dura, resulting in spinal cord herniation 9,12).

Although several theories exist, its exact pathophysiology is still unknown which makes this patient’s cause of cord herniation uncertain. But we anticipated that repeated minor trauma which the patient did not recognize might cause cord herniation because there was no sign of inflammation and specific medical or trauma history.

Thoracic spinal cord herniation has a couple of common characteristics, including ventral herniation at levels T2-8 and subarachnoid cysts. Although the prevalence of ISCH at the thoracic level is still an ongoing debate, its common physiologic characteristics are thought to be kyphosis and limited mobility compared to cervical and lumbar levels 12).

The treatment of choice for an ISCH includes repositioning of the cord and repair of the dural defect with surgery. When repairing the dural defect, we used an artificial dura to overlap the defective area. However, depending on the size and shape, the dural defect may be sutured without overlapping. Also, a recovered neurologic deficit was observed after surgery.

CONCLUSION

ISCH is not a common disease. With improving the quality of imaging tools, it should be considered more for progressive myelopathy patients. Although progressive severe myelopathy might occur, it can be treated with surgical repositioning. Laminoplasty following a cord reposition and dura repair seems to be promising and helpful for preventing CSF leakage and potential deformity, protecting from environmental forces, and insulating against muscle hypotrophy following laminectomy.

Notes

No potential conflict of interest relevant to this article was reported.

References

1. Bhatia K, Madhavan A, Coutinho C, Mathur S. Idiopathic spinal cord herniation. Clin Radiol 75:721–729. 2020;
2. Borges LF, Zervas NT, Lehrich JR. Idiopathic spinal cord herniation: a treatable cause of the Brown-Sequard syndrome-case report. Neurosurgery 36:1028–1032. 1995;
3. Carter BJ, Griffith BD, Schultz LR, Abdulhak MM, Newman DS, Jain R. Idiopathic spinal cord herniation: an imaging diagnosis with a significant delay. Spine J 15:1943–1948. 2015;
4. Dix JE, Griffitt W, Yates C, Johnson B. Spontaneous thoracic spinal cord herniation through an anterior dural defect. AJNR Am J Neuroradiol 19:1345–1348. 1998;
5. Ghali MGZ, Srinivasan VM, Rao VY, Omeis I. Idiopathic thoracic spinal cord herniation. J Clin Neurosci 51:1–5. 2018;
6. Haber MD, Nguyen DD, Li S. Differentiation of idiopathic spinal cord herniation from CSF-isointense intraspinal extramedullary lesions displacing the cord. Radiographics 34:313–329. 2014;
7. Imagama S, Matsuyama Y, Sakai Y, Nakamura H, Katayama Y, Ito Z, et al. Image classification of idiopathic spinal cord herniation based on symptom severity and surgical outcome: a multicenter study. J Neurosurg Spine 11:310–319. 2009;
8. Isu T, Iizuka T, Iwasaki Y, Nagashima M, Akino M, Abe H. Spinal cord herniation associated with an intradural spinal arachnoid cyst diagnosed by magnetic resonance imaging. Neurosurgery 29:137–139. 1991;
9. Nakazawa H, Toyama Y, Satomi K, Fujimura Y, Hirabayashi K. Idiopathic spinal cord herniation. Report of two cases and review of the literature. Spine (Phila Pa 1976) 18:2138–2141. 1993;
10. Sasani M, Ozer AF, Vural M, Sarioglu AC. Idiopathic spinal cord herniation: case report and review of the literature. J Spinal Cord Med 32:86–94. 2009;
11. Tekkök IH. Spontaneous spinal cord herniation: case report and review of the literature. Neurosurgery 46:485–491. 2000;
12. Wortzman G, Tasker RR, Rewcastle NB, Richardson JC, Pearson FG. Spontaneous incarcerated herniation of the spinal cord into a vertebral body: a unique cause of paraplegia. Case report. J Neurosurg 41:631–635. 1974;

Article information Continued

Fig. 1.

Imaging features of idiopathic spinal cord herniation. Magnetic resonance imaging T2 sequence showed a fluid collection at the dorsal portion of the T4-5 level with a sharp angulation of the thoracic cord suggesting ventral protrusion of spinal cord.

Fig. 2.

Sagittal and axial computed tomography myelogram images demonstrating sharp angulation of the thoracic cord, cerebrospinal fluid collection, and widening of the dorsal subarachnoid space.

Fig. 3.

Intraoperative view under a microscope. Herniation of spinal cord and dural defect are also observed. Oval-shaped 2 cm size dural defect and herniation were observed and there was no sign of adhesion or inflammation and spinal cord swelling.

Fig. 4.

Simple pictures for intraoperative view while overlapping the dura. The dura was wrapped with artificial dura. After wrapping, the dura was tightly sutured with continuous suture to prevention recurrence.

Fig. 5.

Simple pictures for intraoperative view while overlapping the dura. The dura was wrapped with artificial dura. After wrapping, the dura was tightly sutured with continuous suture to prevention recurrence.