Image-Guided Neurosurgery Systems with Microscope Integration of Intraoperative 3D-Ultrasound in Neuronavigation

Article information

Nerve. 2021;7(1):27-30
Publication date (electronic) : 2021 April 30
doi : https://doi.org/10.21129/nerve.2021.7.1.27
Department of Neurosurgery, Uijeongbu St. Mary's Hospital, School of Medicine, The Catholic University of Korea, Republic of Korea
Corresponding author: Tae-Kyu Lee, MD, PhD, MBA Department of Neurosurgery, Uijeongbu St. Mary's Hospital, 271, Cheonbo-ro, Uijeongbu-si, Gyeonggi-do 11765, Republic of Korea Tel: +82-31-820-3796, E-mail: dr.lee.taekyu@gmail.com
Received 2020 November 19; Revised 2021 February 14; Accepted 2021 February 15.

INTRODUCTION

Yasargil has brought a paradigm shift to neurosurgery with the use of the microscope12. Recent advances in radiosurgery and endoscopic surgery have challenged in microscopic surgery in the neurosurgical field. However, the more these challenges, the more experienced, and technologies are being accumulated and developed. Through this, the accuracy of surgery is gradually improving. In addition, navigation systems have improved accuracy during surgery and indocyanine green (ICG) angiography has rendered the process easier3,6,11. Furthermore, intraoperative CT and MRI have been used to provide safer and more accurate treatment for patients4,7,10. Herein, our experience of surgery on a patient using the above-mentioned modalities with real-time ultrasound is reported.

CASE REPORT

The patient underwent surgery in 2013 for a posterior fossa hemangioblastoma. There was no recurrence after gross total resection, until a 2-year follow-up MRI. And the patient lost to follow-up. The patient revisited the outpatient department two years later due to recent experience of dizziness and ataxia. The MRI showed local recurrence of hemangioblastoma(Figure 1); therefore, a reoperation was planned.

Figure 1

Preoperative MRI. In the preoperative image, a highly enhancing mass was observed in the posterior fossa with a cystic portion in the mass and another cystic portion in the ventral area of the main mass.

Sub-occipital craniectomy was performed with the patient in the concord position. Upon opening the dura adhesion with arachnoid membrane, CSF was gushed out and the cerebellum was sunken down causing displacement of the cerebellum and tumor; the location was different from that identified using the navigation system. The location of the tumor was confirmed using real-time ultrasound. Threedimensional reconstruction was performed with the ultrasound to overlap the navigation system and confirm the location of the tumor. After the CSF was drained, it was confirmed that the tumor was displaced by as little as 1cm and as much as 3cm compared to the preoperative MRI (Figure 2). The extent of the tumor was confirmed, and the dura was widely opened to expose the tumor. Under the microscope, many red vessels were observed on the surface of the tumor (Figure 3). The vascularity of the tumor was identified using ICG angiography. The tumor was hypervascularity, however, determining the exact position of the feeding artery was difficult due to obstruction by the cerebellar parenchyma (Figure 4). We used realtime Doppler ultrasound to find the feeding artery to the superior margin of the tumor, and there were no other feeders (Figure 5) After blocking the main feeding artery passing over the tumor superiorly, ICG angiography was performed again. The vascularity was significantly reduced (Figure 6). It was judged that all the main feeders were blocked and coagulated, and the tumor was removed enbloc. After controlling bleeding at the tumor removal site, the ope ration was completed with primary wound closure. There were no adverse events during the surgery. The gross total resection of the tumor was confirmed on postoperative MRI (Figure 7). The patient was dis- charged without any other complications.

Figure 2

. Intraoperative real-time ultrasound with neuronavigation. Intraoperative ultrasound image overlaid on preoperative MRI. After CSF was drained, brain shift occurred and the position of the tumor was confirmed using real-time ultrasound.

Figure 3

Microscopic view of the tumor. Many vessels red in color were observed on the surface of the tumor under the microscope.

Figure 4

initial indocyanine green(ICG) angiography. The vascularity of tumor was confirmed very high based on ICG angiography.

Figure 5

Feeding artery identified using real-time Doppler ultrasound. The main feeding artery was identified using Doppler ultrasound before tumor resection and the vessel traveling at the superior margin of the tumor was identified and coagulated.

Figure 6

Final indocyanine green (ICG) angiography. After blocking the feeding artery, the enhancing portion was significantly reduced compared to before blocking.

Figure 7

Post-operative MRI. After the surgery the enhancing lesion was completely removed.

DISCUSSION

Neurosurgery is a complicated field of surgery and requires elaborate work with the major focus being on patient safety. Various modalities such as intraoperative neuro-monitoring, neuro-navigation system, fluorescence, and ICG angiography are used. Intraoperative CT and MRI aid in reducing various risks that may occur during surgery4,7,9,10. However, examination of CT and MRI scans require a considerable amount of time and scans cannot be performed during surgery. In addition, cost-effectiveness is debatable2. Real-time ultrasound can help overcome these problems. It can be applied at a relatively low price, and results can be obtained by conducting inspections in a short time. Recently, several studies have introduced surgery using ultrasound. Manfield et al.5 reported that the ultrasound guided external ventricular drainage is very feasible, and Pepa et al.8 reported that the meningioma feature can be predicted using ultrasound. Dellaretti et al.1. Introduced arteriovenous malformation surgery using doppler ultrasound. As in the present case, real-time ultrasound can help identify vascular lesions allowing early identification of the arterial feeders, thus providing the surgeon with an overall impression of the flow dynamics. In posterior fossa surgery, as in this particular case, the brain shift due to the CSF drain is inevitable. The ultrasound probe is larger in size than the conventional microsurgical instrument, so there is a limit to work in the operative field frequently. However, the use of neuro-navigation solves the problem of the bulky ultrasound probe. Once a 3D image is constructed with an ultrasound probe and overlayed on the MRI of the navigation system, the overlayed ultrasound image can be checked simply using the navigation probe. It can perform imageguided surgery in real-time not inferior to intraoperative MRI. The combination of neuro-navigation and Real-time ultrasound for resection of posterior fossa tumor resection can provide valuable intraoperative information of the location and resection level of the lesion, so it can maximize the extent of resection of the tumor and minimize the complication

METHODS

We used the Zeiss KINEVO microscope(Carl Zeiss AG, Germany), Kick neuro-navigation system(BrainLab, Germany), and BK5000 ultrasound system(BK medical, Germany) for this study.

CONCLUSION

Real-time ultrasound can be used with a navigation system and microscope to provide synergetic benefits for microscopic surgery. The combination of methods can help make surgery more accurate and safer. Also, improved medical services can be provided to patients.

Notes

The authors declare no conflicts of interest.

References

1. Dellaretti M, Ronconi DE. Intraoperative Ultrasound Navigation with Doppler Function to Guide Arteriovenous Malformation Resection: 3-Dimensional Operative Video. Operative Neurosurgery 17:E162–E163. 2019;
2. Eljamel MS, Mahboob SO. The effectiveness and cost-effectiveness of intraoperative imaging in high-grade glioma resection; A comparative review of intraoperative ALA, fluorescein, ultrasound and MRI. Photodiagnosis Photodyn Ther 16:35–43. 2016;
3. Enchev Y. Neuronavigation: Geneology, reality, and prospects. Neurosurg Focus 27:E11. 2009;
4. Henrichs B, Walsh RP. Intraoperative MRI for neurosurgical and general surgical interventions. Curr Opin Anaesthesiol 27:448–452. 2014;
5. Manfield JH, Yu KKH. Real-time ultrasound-guided external ventricular drain placement: Technical note. Neurosurg Focus 43:E5. 2017;
6. Marchese E, Della Pepa GM, La Rocca G, Albanese A, Ius T, Simboli GA, et al. Application of indocyanine green video angiography in vascular neurosurgery. J Neurosurg Sci 63:656–660. 2019;
7. Nimsky C, Ganslandt O, Von Keller B, Romstöck J, Fahlbusch R. Intraoperative high-field-strength MR imaging: implementation and experience in 200 patients. Radiology 233:67–78. 2004;
8. Pepa GMD, Menna G, Stifano V, Pezzullo AM, Auricchio AM, Rapisarda A, et al. Predicting meningioma consistency and brain-meningioma interface with intraoperative strain ultrasound elastography: A novel application to guide surgical strategy. Neurosurgical Focus FOC 50:E15. 2021;
9. Podlesek D, Meyer T, Morgenstern U, Schackert G, Kirsch M. Improved visualization of intracranial vessels with intraoperative coregistration of rotational digital subtraction angiography and intraoperative 3D ultrasound. PLoS One 10e0121345. 2015;
10. Schichor C, Terpolilli N, Thorsteinsdottir J, Tonn JC. Intraoperative Computed Tomography in Cranial Neurosurgery. Neurosurg Clin N Am 28:595–602. 2017;
11. Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: A randomised controlled multicentre phase III trial. Lancet Oncol 7:392–401. 2006;
12. Yasargil MG. A legacy of microneurosurgery: Memoirs, lessons, and axioms. Neurosurgery 45:1025–1092. 1999;

Article information Continued

Figure 1

Preoperative MRI. In the preoperative image, a highly enhancing mass was observed in the posterior fossa with a cystic portion in the mass and another cystic portion in the ventral area of the main mass.

Figure 2

. Intraoperative real-time ultrasound with neuronavigation. Intraoperative ultrasound image overlaid on preoperative MRI. After CSF was drained, brain shift occurred and the position of the tumor was confirmed using real-time ultrasound.

Figure 3

Microscopic view of the tumor. Many vessels red in color were observed on the surface of the tumor under the microscope.

Figure 4

initial indocyanine green(ICG) angiography. The vascularity of tumor was confirmed very high based on ICG angiography.

Figure 5

Feeding artery identified using real-time Doppler ultrasound. The main feeding artery was identified using Doppler ultrasound before tumor resection and the vessel traveling at the superior margin of the tumor was identified and coagulated.

Figure 6

Final indocyanine green (ICG) angiography. After blocking the feeding artery, the enhancing portion was significantly reduced compared to before blocking.

Figure 7

Post-operative MRI. After the surgery the enhancing lesion was completely removed.