| Home | E-Submission | Sitemap | Contact Us |  
top_img
The Nerve > Volume 9(1); 2023 > Article
Choi, Choi, and Lee: Atypical Heterotopic Bone Formation Rear to the Functioning Cervical Artificial Disc Prosthesis Causing Cervical Spondylotic Myelopathy

Abstract

Although heterotopic ossification (HO) might occur in a substantial proportion of cervical disc arthroplasty-switched spinal segments, it is predominantly discovered at the anterior vertebral edges of the treated interspace. Herein, we present the case of a 63-year-old woman who presented with clinical signs of myelopathy almost 5 years after the implantation of a Mobi-C disc prosthesis for C6-7 soft disc herniation. As shown by magnetic resonance imaging and computed tomography, spinal cord compression and a consequent signal change inside the cord were attributed to bony spurs from HO posterior to the still-moving prosthesis. Initial full posterior decompression through C6-7 bilateral laminectomy added to posterior stabilization almost fully relieved the patient’s functional and sensory changes from myelopathy. However, the device, as well as the ectopic bone deposits, had to be removed, and switching to anterior arthrodesis was necessary due to the imminent aggravation and progression of cervical kyphotic curvature from the still-functioning device. To the authors’ knowledge, such extensive bone accumulation posterior to a functional Mobi-C cervical prosthesis causing myelopathy has not yet been reported in the literature. Conversion to solid fusion would be preferred to posterior decompression for the sake of maintaining cervical curvature.

INTRODUCTION

Cervical disc arthroplasty (CDA) is a viable and effective treatment of cervical degenerative disc diseases and has been proposed as an alternative to the conventional anterior cervical discectomy and fusion. The formation of heterotopic ossification (HO) is considered one of the major complications after CDA, which, in the setting of CDA, specifically refers to the undesirable ectopic osteogenesis anterior, posterior, or lateral to the implant and subsequently plays a contradictory role against the fundamental goal of CDA by impeding the range of motion (ROM) of the implanted devices2).
While the majority of studies have focused on the identifications of etiology, risk factors of HO as well as their feasible prevention measures, the question that might be a crucial concern to all surgeons is whether the presence of HO would pose a significant impact on the clinical outcomes has not been properly addressed currently. Moreover, scarce reference could be searched among the past published literatures reporting the accumulation of this HO rear to the previously inserted, moving implant and consequently incurring an unexpected cervical spondylotic myelopathy (CSM)16). This case report describes a patient presented with clinical signs of cervical myelopathy caused by the atypical HO rear to the still functioning cervical artificial disc implant.

CASE REPORT

This 63-year-old female presented with the clinical signs of myelopathy almost 5 years after the initial implantation of a Mobi-C disc prosthesis (Zimmer Biomet, Warsaw, IN, USA) at the C6-7 level due to the left side upper extremity radiculopathy affected with both spinal canal and foraminal stenosis from a local hospital (Fig. 1). Started from approximately a month prior to the referral, an intractable, lancinating pain combined with electricity like paresthesia, especially at the region of the left elbow as well as both palm and fingertips hindered her from the indoor activity at the kitchen, which later rapidly prevailed to refrain her from the outdoor activity due to gait disturbance by paraparesis progression. She showed the dominant radiculopathy and paresthesia at the left C6 and C7 dermatome exaggerated response of both the biceps and triceps brachial reflex, and grade 4 weakness of both lower extremities. The new magnetic resonance imaging on admission surprisingly demonstrated another severe spinal cord compression and consequent swelling and signal change inside the cord at the previously addressed level of C6-7, which was attributed to the bony spurs collections rear to the Mobi-C disc prosthesis as manifested on the concomitant computed tomography scan (Fig. 2).

1. Initial Surgery and Its Consequence

In order to fully decompress the affected spinal cord as well as to offer initial stabilization to the still functioning prosthesis, a posterior full decompressive laminectomy added with C6 lateral mass and C7 pedicle screw fixation was performed. This was originally schemed to avoid any untoward complication occurring during the revision approach or manipulation to resect off the HO that might stick to the ventral aspect of the dura. Upon gentle retraction of the lateral margin of the dura at the axillar portion of the exiting C7 root, the surgeon could directly encounter the expected aberrant, discolored but protruded bony spur mass ventrally affecting the cervical spinal cord (Fig. 3). Dorsal cortical bone over the left side C6 lateral mass had breakage violation during the screw insertion due to simple technical error, which eventually obliged the surgeon to shift the fixation level to the cranial level of C5, unfortunately (Fig. 4A).
Fortunately, the patient showed prompt recovery from her original neurological defect upon initial procedure, with a trace of neuropathic component remnant at the distal part of the upper limb such as fingertip.

2. Second Surgical Procedure and Postoperative Course

The patient managed to be in fair condition, clinically and radiologically, up to two months after the initial procedure till she started to appeal the involuntarily, ‘forwardly tilted neck’ condition on the second visit to the outpatient office. The additional radiograph on lateral posture featured the well-maintained posterior fixation constructs while a concomitantly veered, exaggeratedly flexed but not dislocated moving core inside the Mobi-C artificial disc even during the neutral standing posture with the sagittal vertical axis distance exceeding more than 28 mm (Fig. 4B). Due to the constant discomfort caused by elongated, curved neck posture with subsequent incapability to maintain the proper horizontal gaze, she asked for another surgical corrective measure to overcome this unexpected, deformed status of twice treated neck. The flexed but still functioning prosthesis, as well as the ectopic bone deposited rear to the device for the sake of additional direct decompression of the spinal cord, had to be removed and switched to a firm anterior fusion arthrodesis to provide an immediate correction to the cervical kyphotic curvature change (Fig. 4C).
She also managed to recover fairly even after this second revision surgery and was discharged a few days later leaving a specific expression that describes her condition; she can now ‘look up’ her family without the necessity of rigid external orthosis.

DISCUSSION

HO is defined as the formation of bone outside the skeletal system. It is a well-known phenomenon that might disable patients in total hip or knee joint replacement5,8), but it has also been repeatedly detected in spinal patients after the wide acceptance of CDA. Intraoperative measures to deter the delayed HO development after cervical artificial disc implantation involve a gentle surgical technique, avoidance of muscle trauma, and repetitive rinsing of the surgical field14). Selection of the largest possible caliber for the contacting plate part of the CDA device that might be capable to cover the majority of the surface area for the opened endplates (adequacy of the endplate coverage) could also play a deterrent role against this HO progression by minimizing the unnoticeable discharges from the both above and below vertebral body components11-13). Despite all these efforts, the meta-analysis pooled data from the Kong present the 53.6% and 47.5% prevalence of HO and severe HO respectively within 5 to 10 years after CDA with its positive correlation with the length of follow-up period6).
Although the HO might occur in a substantial proportion of CDA switched spinal segments, but does not appear to lead to a decline in clinical outcomes. Its incidence, progression, clinical Implications, and risk factors based on the long-term outcomes up to seven years have been reported after the usage of Mobi-C device and the trial results have been consistent with the continued non-inferiority of CDA for clinical outcomes and lower cumulative reoperation rates despite up to 26.6% of its incidence3,7). Solid bridging of spurs usually remains asymptomatic and is predominantly discovered at the anterior vertebral edges of the treated interspace merely through routine follow-up radiological examinations1,7,13,15). Some studies demonstrated that the changes in biomechanical factors were associated with the prevalence and/or severity of HO; however, a causal relationship between these factors remains unproven. Hu et al.4) have iterated that a more than 5° increase in immediate post-operative disc space angle and less segmental ROM have conferred a negative effect on HO formation. Meanwhile, Shen et al.10) have previously concluded that endplate coverage of less than 93.8% or intervertebral height change of more than 1.8 mm would exacerbate the non-uniform distribution of stress in the bone-implant interface and promote posterior HO development after cervical disc replacement. Further investigations are warranted to corroborate these risk factors, including multilevel calcified disc herniation, severe spondylosis, and suboptimal placement of the device during primary cervical disc replacement surgery.
Consequently, this unprecedented HO collection rear to the device as well as into the spinal canal eventually incurring the clinical CSM neurologic feature might not have been discovered or anticipated neither by the surgeon or patient herself, although she has been followed up with regular functional radiographs after initial procedure. The authors might suggest the conventional hypothesis that permanent micro stress between the bony endplate and the device, which might have originated from the non-physiologic prosthesis motion, might have promoted osseous spur formation and its enlargement2). Probably an untoward synergy between the non-physiological motions created from the ventrally placed prosthesis with relatively smaller caliber along with the presumably insufficiently resected, remnant dorsal osteophytes might have triggered this appositional bone growth over the residual osteophytes, whose growths are well informed to be promoted by the untoward segmental motion. But there could be no clear elucidation regarding its isolated collection rear to the initial implant, sparing the preferential ventral aspect of the addressed cervical level. Moreover, this presumably consolidated, functionally deprived prosthesis after the secondary posterior fixation surgery was not fully immobilized, retaining its inherent mobility to be flexed. This post-surgical phenomenon suggests the lack of capability for both the posteriorly sealed HO as well as posterior stand-alone fixation to provide firm stability over the functionally deprived cervical motion segment after the untoward artificial disc insertion. As iterated above, a conversion to the solid anterior fusion after full removal of the causative mobile device as well as the ectopic bone deposits would be the preferred revision measure over the simple posterior decompression and fixation for the sake of cervical curvature maintenance.
Recently, there has been data emerging to suggest that the formation of HO might be affected by an increased preoperative signal intensity in the spinal cord, postoperative ROM at the surgical level, and the prosthesis vertebral ratio9). However, it should be noted that, despite these hypotheses, there has been a paucity of consistent evidence. Larger scale investigations are needed to further corroborate the risk factors on the genesis of HO, especially for those lobulated rear to the implant causing CSM as in our case, after CDA.

CONCLUSION

To the author’s knowledge, such extensive bone accumulation posterior to a functional Mobi-C cervical prosthesis causing myelopathy has not yet been reported in the literature. Conversion to a solid anterior fusion after full removal of the causative device as well as the ectopic bone deposits would be preferred to simple posterior decompression for the sake of cervical curvature maintenance.

CONFLICTS OF INTEREST

No potential conflict of interest relevant to this article was reported.

Fig. 1.
T2-weighted sagittal (left upper) and axial (left lower) images from magnetic resonance imaging performed before the initial operation 5 years ago show cervical spondylotic stenosis at C6-7. A postoperative lateral-view radiograph (right) shows a Mobi-C artificial disc placed at the corresponding cervical level.
nerve-2022-00192f1.jpg
Fig. 2.
T2-weighted sagittal (left upper) and axial (left lower) images from magnetic resonance imaging demonstrate severe spinal cord swelling as well as intramedullary high-signal edematous changes corresponding to the previously addressed level of C6-7. A concomitant computed tomography sagittal-view scan (right) reveals a collection of bony spurs rear to the Mobi-C disc prosthesis (arrow).
nerve-2022-00192f2.jpg
Fig. 3.
Intraoperative findings during the initial posterior decompression and fixation procedure. A protruding, dark, discolored, friable bony spur mass impinged the cervical spinal cord ventrally.
nerve-2022-00192f3.jpg
Fig. 4.
An immediate postoperative radiograph after the initial posterior decompression and fixation procedure (A). Due to the dorsal cortical bone manipulative violation during the screw insertion over the left side of the C6 lateral mass, the surgeon was obliged to shift the fixation level to the cranial level. The progression of kyphotic cervical alignment propagating from the flexed conformation of the Mobi-C device was manifested prominently on a lateral radiograph from follow-up a couple of months after initial surgery. The sagittal vertical axis distance exceeded 28 mm (B). A plain lateral-view after the secondary conversion to solid anterior cervical fusion with full removal of the causative mobile device revealed an immediate correction of the cervical kyphotic curvature (C).
nerve-2022-00192f4.jpg

REFERENCES

1. Aghayev E, Bärlocher C, Sgier F, Hasdemir M, Steinsiepe KF, Wernli F, et al.: Five-year results of cervical disc prostheses in the SWISSspine registry. Eur Spine J 22:1723-1730, 2013
crossref pmid pmc pdf
2. Chang PY, Wu JC, Mayo BC, Massel DH, Wang MY: Heterotopic ossification in cervical disc arthroplasty. Contemp Spine Surg 18:1-5, 2017
crossref
3. Davis RJ, Nunley PD, Kim KD, Hisey MS, Jackson RJ, Bae HW, et al.: Two-level total disc replacement with Mobi-C cervical artificial disc versus anterior discectomy and fusion: a prospective, randomized, controlled multicenter clinical trial with 4-year follow-up results. J Neurosurg Spine 22:15-25, 2015
crossref pmid
4. Hu L, Zhang J, Liu H, Meng Y, Yang Y, Li G, et al.: Heterotopic ossification is related to change in disc space angle after Prestige-LP cervical disc arthroplasty. Eur Spine J 28:2359-2370, 2019
crossref pmid pdf
5. Iorio R, Healy WL: Heterotopic ossification after hip and knee arthroplasty: risk factors, prevention, and treatment. J Am Acad Orthop Surg 10:409-416, 2002
crossref pmid
6. Kong L, Ma Q, Meng F, Cao J, Yu K, Shen Y: The prevalence of heterotopic ossification among patients after cervical artificial disc replacement: A systematic review and meta-analysis. Medicine (Baltimore) 96:e7163, 2017
crossref
7. Nunley PD, Cavanaugh DA, Kerr EJ, Utter PA, Campbell PG, Frank KA, et al.: Heterotopic ossification after cervical total disc replacement at 7 years-prevalence, progression, clinical implications, and risk factors. Int J Spine Surg 12:352-361, 2018
crossref pmid pmc
8. Pohl F, Seufert J, Tauscher A, Lehmann H, Springorum HW, Flentje M, et al.: The influence of heterotopic ossification on functional status of hip joint following total hip arthroplasty. Strahlenther Onkol 181:529-533, 2005
crossref pmid pdf
9. Qi M, Chen H, Cao P, Tian Y, Yuan W: Incidence and risk factors analysis of heterotopic ossification after cervical disc replacement. Chin Med J (Engl) 127:3871-3875, 2014
crossref pmid
10. Shen YW, Yang Y, Liu H, Rong X, Ding C, Meng Y, et al.: Effects of endplate coverage and intervertebral height change on heterotopic ossification following cervical disc replacement. J Orthop Surg Res 16:693, 2021
crossref pmid pmc pdf
11. Tu TH, Wu JC, Huang WC, Guo WY, Wu CL, Shih YH, et al.: Heterotopic ossification after cervical total disc replacement: determination by CT and effects on clinical outcomes. J Neurosurg Spine 14:457-465, 2011
crossref pmid
12. Tu TH, Wu JC, Huang WC, Wu CL, Ko CC, Cheng H: The effects of carpentry on heterotopic ossification and mobility in cervical arthroplasty: determination by computed tomography with a minimum 2-year follow-up: Clinical article. J Neurosurg Spine 16:601-609, 2012
crossref pmid
13. Wenger M, Hoonacker P, Zachee B, Lange R, Markwalder TM: Bryan cervical disc prostheses: preservation of function over time. J Clin Neurosci 16:220-225, 2009
crossref pmid
14. Wenger M, Markwalder TM: Bryan total disc arthroplasty: a replacement disc for cervical disc disease. Med Devices (Auckl) 3:11-24, 2010
crossref pmid pmc
15. Wenger M, Markwalder TM: Posterior decompression salvages Bryan total disc arthroplasty in post-operatively recurrent uncoforaminal stenosis. J Clin Neurosci 21:741-744, 2014
crossref pmid
16. Wenger M, Markwalder TM: Heterotopic ossification associated with myelopathy following cervical disc prosthesis implantation. J Clin Neurosci 26:154-156, 2016
crossref pmid
TOOLS
PDF Links  PDF Links
PubReader  PubReader
ePub Link  ePub Link
XML Download  XML Download
Full text via DOI  Full text via DOI
Download Citation  Download Citation
  Print
Share:      
METRICS
0
Crossref
2,532
View
43
Download
Related article
Editorial Office
Department of Neurosurgery, Dankook University Hospital
201, Manghyang-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do 31116, South Korea
TEL: +0082-41-550-6280   FAX: +82-41-556-0524   
E-mail: spine1225@naver.com , mousehunt7@naver.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © The Korean Society of Peripheral Nervous System.                 Developed in M2PI